ETH-LAD — Research Content

Description

ETH-LAD is a semi-synthetic lysergamide derived from LSD (lysergic acid diethylamide). It is structurally similar to LSD with an ethyl substitution at the 6-position. ETH-LAD is used in laboratory research to study serotonergic receptor activity and the pharmacology of lysergamides.

Potency and Effects

ETH-LAD is slightly more potent than LSD in both animals and humans. In rodent drug discrimination tests, it is about 1.6- to 2.3-fold more potent than LSD. The typical human oral dose range is 20 to 150 μg, compared to 50 to 200 μg for LSD, making it roughly twice as potent as LSD in humans. Duration of effects is 8–12 hours, similar to LSD.

Qualitative effects are similar to LSD. According to anecdotal reports in TiHKAL by Alexander Shulgin, ETH-LAD is described as more gentle, less pushy or aggressive, but with slightly less of LSD's "sparkle". Visual distortions are present but modified relative to LSD.

Behavioral & Physiological Effects (Observed in Research)

- Effects include altered perception, visual hallucinations, mood changes, and altered cognition. 
- Animal studies demonstrate serotonergic activation, receptor binding specificity, and behavioral alterations. 
- Human effects are extrapolated; direct research in humans is limited and strictly regulated.

Safety and Legal Considerations